Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.70 |
| ▸ | PDE4A | P27815 | 18/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.70 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29993300 | 0.82 | PDE4D (1.00) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL4702803 | 0.82 | PDE4D (1.00) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL432864 | 0.82 | PDE4A (0.77) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL8290205 | 0.82 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| Sch-351591 SCHEMBL157018 | 0.82 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| Sch-351591 SCHEMBL29378661 | 0.82 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL7424198 | 0.80 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL13035036 | 0.79 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL432865 | 0.78 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL7982331 | 0.76 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2010513276-A | — | — | 2010-04-30 | — | — | JP | claimed |
| EP-2125841-A1 | MONOPHOSPHATES AS MUTUAL PRODRUGS OF ANTI-INFLAMMATORY SIGNAL TRANSDUCTION MODULATORS (AISTM'S) AND BETA-AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION | Gilead Sciences, Inc. (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008076265-A1 | MONOPHOSPHATES AS MUTUAL PRODRUGS OF ANTI-INFLAMMATORY SIGNAL TRANSDUCTION MODULATORS (AISTM'S) AND β-AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION | GILEAD SCIENCES, INC. (US) | 2008-06-26 | — | — | WO | claimed |