Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | ME2 | P23368 | 1/20 | 0.54 |
| ▸ | ME1 | P48163 | 1/20 | 0.54 |
| ▸ | ME3 | Q16798 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10721826 | 0.83 | MEN1 (1.00) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL14578661 | 0.82 | ALDH1A1 (0.78) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL29516320 | 0.80 | MEN1 (0.86) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL16002928 | 0.79 | MEN1 (0.68) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL10064244 | 0.79 | MEN1 (0.83) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL5353584 | 0.78 | GRIN2B (0.68) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| Hydrochloric Acid SCHEMBL19691813 | 0.78 | SMN1; SMN2 (0.58) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL16000506 | 0.77 | MEN1 (0.64) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL652552 | 0.76 | MEN1 (0.78) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL6390973 | 0.76 | MEN1 (0.84) | KMT2AMEN1ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343069-A1 | Heterocyclic aspartyl protease inhibitors | Schering Corporation (US) | 2011-07-13 | — | — | EP | disclosed |
| WO-2005058311-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2005-06-30 | — | — | WO | disclosed |