Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | UBE2N | P61088 | 2/20 | 0.75 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290333 | 0.81 | ALDH1A1 (1.00) | KMT2AMEN1KDM4EUBE2NRXFP1 | |
| SCHEMBL4090933 | 0.78 | KMT2A (0.66) | KMT2AMEN1KDM4EUBE2NRXFP1 | |
| SCHEMBL18300711 | 0.78 | KMT2A (0.65) | KMT2AMEN1KDM4EUBE2NRXFP1 | |
| SCHEMBL15347034 | 0.77 | POLB (0.81) | KDM4EALDH1A1LMNATHRBPOLB | |
| SCHEMBL18300329 | 0.77 | KMT2A (0.64) | KMT2AMEN1KDM4EUBE2NRXFP1 | |
| SCHEMBL18300584 | 0.76 | ALDH1A1 (0.68) | KMT2AMEN1KDM4EUBE2NRXFP1 | |
| SCHEMBL18309615 | 0.76 | ALDH1A1 (0.68) | KMT2AMEN1KDM4EUBE2NRXFP1 | |
| SCHEMBL34468492 | 0.76 | POLB (0.68) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL8288732 | 0.76 | POLB (0.78) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL34468594 | 0.76 | POLB (0.62) | KMT2AMEN1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |