Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.46 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986490 | 0.84 | ALDH1A1 (0.63) | TSHRNPSR1LMNAATMALDH1A1 | |
| SCHEMBL3986487 | 0.84 | ALDH1A1 (0.63) | TSHRNPSR1LMNAATMALDH1A1 | |
| SCHEMBL8288736 | 0.82 | TSHR (0.95) | TSHRNPSR1LMNAATMALDH1A1 | |
| SCHEMBL3985021 | 0.78 | MAPT (0.70) | NPSR1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3985017 | 0.78 | MAPT (0.70) | NPSR1LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19197517 | 0.78 | ALDH1A1 (0.52) | TSHRNPSR1LMNAATMALDH1A1 | |
| SCHEMBL17372925 | 0.76 | MAPT (0.62) | TSHRNPSR1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL19180612 | 0.76 | MAPT (0.62) | TSHRNPSR1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL17378590 | 0.76 | MAPT (0.62) | TSHRNPSR1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8288610 | 0.72 | ALDH1A1 (0.69) | TSHRNPSR1LMNAATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |