Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | HPGD | P15428 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719679 | 0.80 | ALDH1A1 (0.57) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL1719520 | 0.79 | ALDH1A1 (1.00) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL21247269 | 0.75 | MAPT (0.74) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL21247141 | 0.75 | MAPT (0.74) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL3986618 | 0.75 | MAPT (0.74) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL2944021 | 0.72 | MAPT (0.72) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL14433570 | 0.71 | DRD3 (0.51) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL8289737 | 0.70 | MAPT (0.58) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL14625798 | 0.69 | LIMK1 (0.71) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL1719517 | 0.69 | MAPT (0.75) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |