Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368847 | 0.88 | HDAC1 (0.75) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL3368850 | 0.88 | HDAC1 (0.75) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL8290485 | 0.79 | HDAC1 (0.53) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL832728 | 0.73 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL832727 | 0.73 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL830908 | 0.73 | HDAC1 (0.83) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| SCHEMBL830907 | 0.73 | HDAC1 (0.83) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| Pracinostat SCHEMBL833106 | 0.72 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| Pracinostat SCHEMBL29351549 | 0.72 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC2HDAC6 | |
| Pracinostat SCHEMBL833105 | 0.72 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005028447-A1 | BENZIMIDAZOLE DERIVATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S*BIO PTE LTD (SG) | 2005-03-31 | — | — | WO | disclosed |