Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9944381 | 0.81 | NAPRT (0.56) | NAPRTMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL4829341 | 0.79 | NAPRT (0.46) | NAPRTMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL1811012 | 0.73 | NAPRT (0.68) | NAPRTMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL4406065 | 0.73 | NAPRT (0.58) | NAPRTMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL8020133 | 0.73 | NAPRT (0.61) | NAPRTMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL21209660 | 0.72 | NAPRT (0.56) | NAPRTMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1034880 | 0.71 | NAPRT (0.63) | NAPRTMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL2416419 | 0.70 | NAPRT (0.58) | NAPRTMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL17106631 | 0.70 | NAPRT (0.62) | NAPRTMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL27612856 | 0.69 | NAPRT (0.73) | NAPRTMAPTLMNAKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005028475-A2 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |