SCHEMBL8292452

SCHEMBL8292452

Nc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Cl)cc2)cc1

nearest known ligand 0.86

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 14/20 0.86
PTGS1 P23219 10/20 0.86
PDPK1 O15530 3/20 0.71
CYP2C9 P11712 2/20 0.70
CYP1A2 P05177 1/20 0.70
CYP3A4 P08684 1/20 0.70
TSHR P16473 1/20 0.70
CYP2C19 P33261 1/20 0.70
THPO P40225 1/20 0.70
BLM P54132 1/20 0.70
PMP22 Q01453 1/20 0.70
HIF1A Q16665 1/20 0.70
NPSR1 Q6W5P4 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7113078 0.93 PTGS2 (1.00) PTGS2PTGS1PDPK1CYP2C9CYP1A2
SCHEMBL18448102 0.87 PTGS2 (0.72) PTGS2PTGS1PDPK1CYP2C9CYP3A4
SCHEMBL2697564 0.87 PTGS2 (0.65) PTGS2PTGS1PDPK1CYP2C9CYP1A2
SCHEMBL6247556 0.86 PTGS2 (0.86) PTGS2PTGS1PDPK1CYP2C9CYP1A2
SCHEMBL14345166 0.86 PTGS2 (0.86) PTGS2PTGS1PDPK1CYP2C9CYP1A2
SCHEMBL4588503 0.86 PTGS2 (0.86) PTGS2PTGS1PDPK1CYP2C9CYP1A2
SCHEMBL5694394 0.86 PTGS2 (0.86) PTGS2PTGS1PDPK1CYP2C9CYP1A2
SCHEMBL12213580 0.86 PDPK1 (0.73) PTGS2PTGS1PDPK1CYP2C9
SCHEMBL2698251 0.86 PTGS1 (0.76) PTGS2PTGS1PDPK1CYP2C9
SCHEMBL14747609 0.86 PTGS2 (0.74) PTGS2PTGS1PDPK1CYP2C9CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005046615-A2 COMPOSITIONS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM MEDIATED DISORDERS PHARMACIA & UPJOHN COMPANY LLC (US) 2005-05-26 WO disclosed
WO-2005018563-A2 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A PHOSPHODIESTERASE INHIBITOR FOR THE TREATMENT OF ISCHEMIC MEDIATED CENTRAL NERVOUS SYSTEM DISORDERS OR INJURY PHARMACIA CORPORATION (US) 2005-03-03 WO disclosed
WO-2004105699-A2 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A CANNABINOID AGENT FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE PHARMACIA CORPORATION (US) 2004-12-09 WO disclosed
WO-2004103286-A2 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A CHOLIMERGIC AGENT PHARMACIA CORPORATION (US) 2004-12-02 WO disclosed
WO-2004093816-A2 COMPOSITIONS COMPRISING A SELECTIVE COX-2 INHIBITOR AND A CALCIUM MODULATING AGENT PHARMACIA CORPORATION (US) 2004-11-04 WO disclosed
WO-2004093811-A2 COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A SODIUM ION CHANNEL BLOCKER FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE PHARMACIA CORPORATION (US) 2004-11-04 WO disclosed