Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 12/20 | 0.64 |
| ▸ | SLC6A5 | Q9Y345 | 8/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | IDE | P14735 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925925 | 0.92 | SLC6A9 (0.77) | SLC6A9SLC6A5SMN1; SMN2IDEPAX8 | |
| SCHEMBL3919342 | 0.85 | SLC6A9 (0.77) | SLC6A9SLC6A5KDM4ESMN1; SMN2LMNA | |
| SCHEMBL3917883 | 0.79 | SLC6A9 (0.74) | SLC6A9SLC6A5SMN1; SMN2IDEPAX8 | |
| SCHEMBL3918885 | 0.78 | SLC6A9 (1.00) | SLC6A9SLC6A5SMN1; SMN2IDEPAX8 | |
| SCHEMBL3923118 | 0.77 | SLC6A9 (1.00) | SLC6A9SLC6A5SMN1; SMN2IDEPAX8 | |
| SCHEMBL3918757 | 0.77 | SLC6A9 (0.82) | SLC6A9SLC6A5SMN1; SMN2IDEPAX8 | |
| SCHEMBL13687929 | 0.77 | SLC6A9 (1.00) | SLC6A9SLC6A5SMN1; SMN2IDEPAX8 | |
| SCHEMBL3918168 | 0.77 | SLC6A9 (0.82) | SLC6A9SLC6A5SMN1; SMN2IDEPAX8 | |
| SCHEMBL13687921 | 0.76 | SLC6A9 (0.81) | SLC6A9SLC6A5SMN1; SMN2IDEPAX8 | |
| SCHEMBL3921705 | 0.76 | SLC6A9 (0.77) | SLC6A9SLC6A5SMN1; SMN2IDEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005023260-A1 | 1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-17 | — | — | WO | disclosed |