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SCHEMBL8294607

SCHEMBL8294607

CCNS(=O)(=O)c1ccc(-c2ccccc2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1

nearest known ligand 0.77

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ SLC6A9 P48067 12/20 0.77
▸ KCNH2 Q12809 1/20 0.49
▸ POLB P06746 1/20 0.48
▸ HTR7 P34969 1/20 0.47
▸ CNR1 P21554 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ GPR55 Q9Y2T6 1/20 0.44
▸ RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4425316 0.90 SLC6A9 (0.81) SLC6A9KCNH2ALDH1A1HTTGPR55
SCHEMBL4422319 0.87 SLC6A9 (1.00) SLC6A9KCNH2GPR55
SCHEMBL3920951 0.85 SLC6A9 (0.75) SLC6A9KCNH2CNR1ALDH1A1HTT
SCHEMBL3928202 0.82 SLC6A9 (0.77) SLC6A9
SCHEMBL4435392 0.82 SLC6A9 (0.92) SLC6A9KCNH2GPR55
SCHEMBL4426854 0.80 SLC6A9 (0.85) SLC6A9KCNH2GPR55
SCHEMBL5037924 0.79 SLC6A9 (0.60) SLC6A9KCNH2
SCHEMBL4424645 0.79 SLC6A9 (0.85) SLC6A9KCNH2GPR55
SCHEMBL4426303 0.79 SLC6A9 (0.84) SLC6A9KCNH2GPR55
SCHEMBL4422354 0.79 SLC6A9 (1.00) SLC6A9KCNH2GPR55

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005023261-A1 1-BENZOYL-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES F. HOFFMANN-LA ROCHE AG (CH) 2005-03-17 — — WO disclosed