Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857118 | 0.86 | KDM4E (0.67) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL858141 | 0.84 | KDM4E (0.65) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL8295983 | 0.84 | ALDH1A1 (0.56) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL6837800 | 0.83 | KDM4E (0.67) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL14419887 | 0.82 | KDM4E (0.51) | KDM4ELMNAALDH1A1HSD17B10PARP1 | |
| SCHEMBL6729531 | 0.79 | ALDH1A1 (1.00) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL4475519 | 0.79 | KDM4E (0.76) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL11271758 | 0.78 | KDM4E (0.73) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL4467144 | 0.78 | KDM4E (0.73) | KDM4ELMNAALDH1A1HSD17B10MAPT | |
| SCHEMBL22825094 | 0.75 | KDM4E (0.69) | KDM4ELMNAALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003122-A1 | 5HT4-ANTAGONISTIC 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-13 | — | — | WO | disclosed |