Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.62 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21745729 | 0.81 | PRSS1 (0.54) | PRSS1PRSS2PRSS3PARP1CES2 | |
| SCHEMBL8294719 | 0.79 | PRSS1 (0.57) | PRSS1PRSS2PRSS3PARP1CES2 | |
| SCHEMBL24454583 | 0.79 | PRSS1 (0.65) | PRSS1PRSS2PRSS3PARP1CES2 | |
| SCHEMBL23815322 | 0.77 | PARP1 (0.48) | PARP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL428920 | 0.77 | PRSS1 (1.00) | PRSS1PRSS2PRSS3PARP1CES2 | |
| SCHEMBL8269868 | 0.75 | PARP1 (0.59) | PRSS1PRSS2PRSS3PARP1CES2 | |
| Hydrochloric Acid SCHEMBL427173 | 0.75 | PRSS1 (0.96) | PRSS1PRSS2PRSS3PARP1CES2 | |
| Hydrochloric Acid SCHEMBL23541004 | 0.75 | PRSS1 (0.96) | PRSS1PRSS2PRSS3PARP1CES2 | |
| Hydrochloric Acid SCHEMBL28548914 | 0.75 | PRSS1 (0.96) | PRSS1PRSS2PRSS3PARP1CES2 | |
| SCHEMBL4971524 | 0.74 | PRSS1 (0.69) | PRSS1PRSS2PRSS3PARP1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |