Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | APP | P05067 | 6/20 | 0.71 |
| ▸ | SNCA | P37840 | 6/20 | 0.71 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296195 | 1.00 | MAPT (0.71) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL7678890 | 0.94 | APP (0.75) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL7678889 | 0.94 | APP (0.75) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL7671182 | 0.85 | MAPT (0.58) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL7671185 | 0.85 | MAPT (0.58) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL7676181 | 0.82 | APP (0.57) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL29158518 | 0.80 | MAPT (0.66) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL7676746 | 0.78 | APP (0.53) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL7672585 | 0.77 | APP (0.52) | MAPTAPPSNCAHCRTR1ALDH1A1 | |
| SCHEMBL7672581 | 0.77 | APP (0.52) | MAPTAPPSNCAHCRTR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532054-B1 | Process for preparing alpha,alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | DU PONT PHARM CO (US) | 1999-06-09 | — | — | EP | disclosed |
| EP-0623127-B1 | NOVEL NEUROTRANSMITTER RELEASERS USEFUL FOR COGNITION ENHANCEMENT | DU PONT MERCK PHARMA (US) | 1997-04-02 | — | — | EP | disclosed |
| US-5532247-A | ACENAPHTHENES SUBSTITUTED IN THE 1-POSITION BY PYRIDYLMETHYL OR FLUOROPYRIDYLMETHYL; TREATING COGNITIVE OR NEUROLOGICAL DYSFUNCTION THEREWITH | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-02 | — | — | US | disclosed |
| US-5434264-A | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-18 | — | — | US | disclosed |
| US-5414004-A | Cognitive activators and nervous system disorders | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-05-09 | — | — | US | disclosed |
| US-5300642-A | α, α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0532054-A1 | Process for preparing alpha,alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| US-5173489-A | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DUPONT MERCK PHARMACEUTICAL CO. (US) | 1992-12-22 | — | — | US | disclosed |
| EP-0311010-A2 | Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1989-04-12 | — | — | EP | disclosed |
| EP-0311029-A2 | Process for preparing 3,3-disubstituted indolines | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1989-04-12 | — | — | EP | disclosed |
| US-4806651-A | Process for preparing 3,3-disubstituted indolines | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-02-21 | — | — | US | disclosed |