Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | SNCA | P37840 | 8/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672585 | 0.87 | APP (0.52) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL7672581 | 0.87 | APP (0.52) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL7678889 | 0.81 | APP (0.75) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL7678890 | 0.81 | APP (0.75) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL7678131 | 0.80 | MAPT (0.50) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL7679531 | 0.80 | TRPA1 (0.50) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL7679532 | 0.80 | TRPA1 (0.50) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL7678126 | 0.80 | MAPT (0.50) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL8296193 | 0.78 | MAPT (0.71) | APPMAPTSNCAHCRTR1ERBB2 | |
| SCHEMBL8296195 | 0.78 | MAPT (0.71) | APPMAPTSNCAHCRTR1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | OSI PHARMACEUTICALS, INC. | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | TP53, MYC, VHL | APP 4305/4885MAPT 2381/4885SNCA 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.