Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16614204 | 0.87 | IDO1 (0.45) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL4568016 | 0.86 | IDO1 (0.44) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL31021659 | 0.84 | IDO1 (0.46) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL17230177 | 0.84 | IDO1 (0.46) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL5241843 | 0.84 | AKR1C3 (0.48) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31021847 | 0.83 | IDO1 (0.46) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL17930966 | 0.83 | IDO1 (0.46) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL21734883 | 0.80 | IDO1 (0.44) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL3787046 | 0.79 | KMT2A (0.54) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 | |
| SCHEMBL13404531 | 0.78 | PTGER1 (0.41) | IDO1HSP90AA1HSP90AB1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067986-C | 1H-indole-3-acetic acid hydrazide spla2 inhibitors | LILLY CO ELI (US) | 2001-07-04 | — | — | CN | disclosed |
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |