Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KDM5C | P41229 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL31317587 | 1.00 | FFAR3 (0.50) | FFAR3LCKFYNKISS1RKDM4E | |
| Acetic Acid SCHEMBL7114741 | 1.00 | FFAR3 (0.50) | FFAR3LCKFYNKISS1RKDM4E | |
| Acetic Acid SCHEMBL10583214 | 0.88 | FFAR3 (0.39) | FFAR3LCKFYNKISS1RKDM4E | |
| Acetic Acid SCHEMBL1832152 | 0.84 | — | — | |
| Acetic Acid SCHEMBL7116725 | 0.84 | CYP2C19 (0.38) | FFAR3LCKFYNKISS1RALDH1A1 | |
| Carbamic Acid SCHEMBL144323 | 0.83 | ACHE (0.47) | FFAR3KISS1RKDM4ELDHASRR | |
| Acetic Acid SCHEMBL3002126 | 0.82 | — | — | |
| Acetic Acid SCHEMBL16792629 | 0.82 | — | — | |
| Acetic Acid SCHEMBL5950878 | 0.82 | FFAR3 (0.39) | FFAR3LCKFYNKISS1RKDM4A | |
| Acetic Acid SCHEMBL29210800 | 0.82 | PAOX (0.39) | FFAR3LCKFYNKISS1RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957549-B2 | Compositions and methods for negative selection of non-desired nucleic acid sequences | NUGEN TECHNOLOGIES, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| EP-2861787-B1 | COMPOSITIONS AND METHODS FOR NEGATIVE SELECTION OF NON-DESIRED NUCLEIC ACID SEQUENCES | NUGEN TECH INC (US) | 2017-09-20 | — | — | EP | disclosed |
| US-20160362680-A1 | COMPOSITIONS AND METHODS FOR NEGATIVE SELECTION OF NON-DESIRED NUCLEIC ACID SEQUENCES | NUGEN TECHNOLOGIES, INC. | 2016-12-15 | — | — | US | disclosed |
| US-20150299767-A1 | COMPOSITIONS AND METHODS FOR NEGATIVE SELECTION OF NON-DESIRED NUCLEIC ACID SEQUENCES | NUGEN TECHNOLOGIES, INC. | 2015-10-22 | — | — | US | disclosed |
| EP-2861787-A2 | COMPOSITIONS AND METHODS FOR NEGATIVE SELECTION OF NON-DESIRED NUCLEIC ACID SEQUENCES | Nugen Technologies, Inc. (US) | 2015-04-22 | — | — | EP | disclosed |
| US-20140065692-A1 | Methods for Fragmentation and Labeling of Nucleic Acids | NUGEN TECHNOLOGIES INC (US) | 2014-03-06 | — | — | US | disclosed |
| WO-2013191775-A2 | COMPOSITIONS AND METHODS FOR NEGATIVE SELECTION OF NON-DESIRED NUCLEIC ACID SEQUENCES | NUGEN TECHNOLOGIES, INC. (US) | 2013-12-27 | — | — | WO | disclosed |
| US-8551709-B2 | Methods for fragmentation and labeling of nucleic acids | NUGEN TECHNOLOGIES, INC. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120220483-A1 | METHODS FOR FRAGMENTATION AND LABELING OF NUCLEIC ACIDS | NUGEN TECHNOLOGIES, INC. (US) | 2012-08-30 | — | — | US | disclosed |
| EP-2464738-A1 | METHODS, COMPOSITIONS, AND KITS FOR GENERATING NUCLEIC ACID PRODUCTS SUBSTANTIALLY FREE OF TEMPLATE NUCLEIC ACID | Nugen Technologies, Inc. (US) | 2012-06-20 | — | — | EP | disclosed |
| US-8143001-B2 | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids | NUGEN TECHNOLOGIES, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110224105-A1 | METHODS, COMPOSITIONS, AND KITS FOR GENERATING NUCLEIC ACID PRODUCTS SUBSTANTIALLY FREE OF TEMPLATE NUCLEIC ACID | NUGEN TECHNOLOGIES, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| WO-2011019964-A9 | METHODS, COMPOSITIONS, AND KITS FOR GENERATING NUCLEIC ACID PRODUCTS SUBSTANTIALLY FREE OF TEMPLATE NUCLEIC ACID | NUGEN TECHNOLOGIES, INC. (US) | 2011-08-04 | — | — | WO | disclosed |
| WO-2011019964-A1 | METHODS, COMPOSITIONS, AND KITS FOR GENERATING NUCLEIC ACID PRODUCTS SUBSTANTIALLY FREE OF TEMPLATE NUCLEIC ACID | NUGEN TECHNOLOGIES, INC. (US) | 2011-02-17 | — | — | WO | disclosed |
| US-20100022403-A1 | METHODS FOR FRAGMENTATION AND LABELING OF NUCLEIC ACIDS | KURN NURITH | 2010-01-28 | — | — | US | disclosed |
| US-20090233804-A1 | METHODS FOR ANALYSIS OF NUCLEIC ACID METHYLATION STATUS AND METHODS FOR FRAGMENTATION, LABELING AND IMMOBILIZATION OF NUCLEIC ACIDS | NUGEN TECHNOLOGIES, INC. | 2009-09-17 | — | — | US | disclosed |
| US-20050208538-A1 | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids | NUGEN TECHNOLOGIES, INC. | 2005-09-22 | — | — | US | disclosed |
| US-20040005614-A1 | Methods for fragmentation, labeling and immobilization of nucleic acids | NUGEN TECHNOLOGIES, INC. | 2004-01-08 | — | — | US | disclosed |
| US-4672136-A | Monoadduct monomers and polyadduct polymers from divinyl ketones | THE DOW CHEMICAL COMPANY (US) | 1987-06-09 | — | — | US | disclosed |