SCHEMBL8299377

SCHEMBL8299377

O=C(NC1CCN(c2ncccc2[N+](=O)[O-])C1)c1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.65
MAPT P10636 3/20 0.65
AKT1 P31749 1/20 0.52
CYP1A2 P05177 2/20 0.51
CYP2C9 P11712 2/20 0.51
CYP2C19 P33261 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
CRHBP P24387 2/20 0.49
CRHR2 Q13324 2/20 0.49
GRM5 P41594 1/20 0.48
LMNA P02545 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
CTSL P07711 1/20 0.46
CTSB P07858 1/20 0.46
CTSK P43235 1/20 0.46
ACKR3 P25106 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
CKS1B P61024 1/20 0.45
SKP1 P63208 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12126266 0.94 ALDH1A1 (0.71) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL12126169 0.91 ALDH1A1 (0.60) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL12124637 0.83 GRM5 (0.62) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL3281579 0.82 ALDH1A1 (0.66) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL3281568 0.82 ALDH1A1 (0.66) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL14334518 0.79 ALDH1A1 (0.68) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL6210805 0.79 ALDH1A1 (1.00) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL13218257 0.79 MAPT (0.65) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19
SCHEMBL27884884 0.78 NAMPT (0.53) ALDH1A1MAPTAKT1CYP2C9CYP2C19
SCHEMBL27665090 0.76 ALDH1A1 (0.53) ALDH1A1MAPTCYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7767699-B2 Therapeutic agents useful for treating pain PURDUE PHARMA, L.P. (US) 2010-08-03 US disclosed
EP-1641775-B1 2-PYRIDINE ALKYNE DERIVATIVES USEFUL FOR TREATING PAIN EURO CELTIQUE SA (LU) 2009-02-18 EP disclosed
WO-2005007641-A1 2-PYRIDINE ALKYNE DERIVATIVES USEFUL FOR TREATING PAIN EURO-CELTIQUE S.A. (LU) 2005-01-27 WO disclosed