SCHEMBL8299561

SCHEMBL8299561

C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3csc(NC(C)=O)n3)nc3c(CC)c(OC)ccc23)CN1C(=O)[C@@H](N)C(C)(C)C)C(=O)O

nearest known ligand 0.65

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CTSB P07858 1/20 0.65
PPP3CB P16298 1/20 0.65
ABCC1 P33527 1/20 0.46
ABCC2 Q92887 1/20 0.46
ABCG2 Q9UNQ0 1/20 0.46
CYP3A4 P08684 2/20 0.39
ADRB3 P13945 1/20 0.37
ADRA2B P18089 1/20 0.37
ADRA2C P18825 1/20 0.37
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
ALOX15 P16050 1/20 0.31
MAPK1 P28482 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10137366 0.90 CTSB (0.81) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL12140919 0.87 CTSB (0.69) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL10137400 0.84 CTSB (0.78) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL8300231 0.83 CTSB (0.82) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL10137440 0.82 CTSB (0.70) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL8300236 0.82 CTSB (0.67) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL10137402 0.82 CTSB (0.69) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL10221275 0.81 CTSB (0.62) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL10137361 0.80 CTSB (0.70) CTSBPPP3CBABCC1ABCC2ABCG2
SCHEMBL12140974 0.80 CTSB (0.70) CTSBPPP3CBABCC1ABCC2ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004103996-A1 HEPATITIS C INHIBITOR COMPOUNDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2004-12-02 WO disclosed