Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4625142 | 0.82 | ALOX5 (0.57) | ALOX5PTGESGAAKDM4ETDP1 | |
| SCHEMBL27916400 | 0.80 | ALOX5 (0.64) | ALOX5PTGESGAAKDM4ETDP1 | |
| SCHEMBL28005923 | 0.77 | MAPT (0.59) | ALOX5PTGESGAAKDM4ETDP1 | |
| SCHEMBL10091157 | 0.74 | ESR1 (0.56) | TDP1MAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3082334 | 0.74 | TSHR (0.57) | ALOX5GAAMAPTALDH1A1MEN1 | |
| SCHEMBL27634632 | 0.73 | TSHR (0.55) | ALOX5PTGESGAAMAPTALDH1A1 | |
| SCHEMBL28268729 | 0.73 | TSHR (0.55) | ALOX5GAAMAPTALDH1A1MEN1 | |
| SCHEMBL4625267 | 0.72 | ALOX5 (0.57) | ALOX5PTGESGAAKDM4ETDP1 | |
| SCHEMBL4625153 | 0.72 | ALOX5 (0.64) | ALOX5PTGESGAAKDM4ETDP1 | |
| SCHEMBL27916403 | 0.72 | ALOX5 (1.00) | ALOX5PTGESGAAKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005041904-A2 | INHIBITORS OF CORONAVIRUS PROTEASE AND METHODS OF USE THEREOF | FULCRUM PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |