Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026641 | 0.90 | CYP19A1 (0.47) | CYP19A1CYP11B1CYP11B2MAPTRXFP1 | |
| SCHEMBL8298813 | 0.82 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2MAPTLMNA | |
| SCHEMBL3995780 | 0.81 | KMT2A (0.46) | CYP19A1CYP11B1CYP11B2MAPTRXFP1 | |
| SCHEMBL8301408 | 0.80 | PDE4B (0.45) | CYP19A1CYP11B1CYP11B2MAPTALDH1A1 | |
| SCHEMBL8302105 | 0.78 | PDE4B (0.51) | CYP19A1CYP11B1CYP11B2MAPTTSHR | |
| SCHEMBL8302112 | 0.78 | NPC1 (0.46) | CYP19A1CYP11B1CYP11B2MAPTTSHR | |
| SCHEMBL14364592 | 0.78 | RXFP1 (0.54) | CYP19A1CYP11B1CYP11B2MAPTRXFP1 | |
| SCHEMBL8298197 | 0.77 | CYP19A1 (0.47) | CYP19A1CYP11B1CYP11B2KMT2AF2RL1 | |
| SCHEMBL5022276 | 0.76 | EDNRA (0.49) | MAPTTSHRALDH1A1HPGDKDM4E | |
| SCHEMBL5022652 | 0.75 | CYP19A1 (0.47) | CYP19A1CYP11B1CYP11B2MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111044-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS:PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-12-23 | — | — | WO | disclosed |