Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.38 |
| ▸ | CDC14B | O60729 | 2/20 | 0.36 |
| ▸ | CDC14A | Q9UNH5 | 2/20 | 0.36 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.36 |
| ▸ | EPM2A | O95278 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5018032 | 0.90 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL8298813 | 0.88 | CYP19A1 (0.45) | PDE4BKDM4EALDH1A1MAPTF2RL1 | |
| SCHEMBL8298298 | 0.81 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL8299604 | 0.80 | CYP19A1 (0.45) | KDM4EALDH1A1MAPTHPGDF2RL1 | |
| SCHEMBL8298197 | 0.80 | CYP19A1 (0.47) | PDE4BPDE4DPDE4APDE4CF2RL1 | |
| SCHEMBL8300121 | 0.78 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL8298827 | 0.78 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL5026501 | 0.78 | PDE4D (0.51) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL5026521 | 0.77 | CYP19A1 (0.47) | PDE4BKDM4EALDH1A1MAPTF2RL1 | |
| SCHEMBL8272313 | 0.77 | HTT (0.44) | PDE4BPDE4DPDE4APDE4CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111044-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS:PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-12-23 | — | — | WO | disclosed |