Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4625149 | 0.83 | ALOX5 (0.64) | NR1H4ALOX5PTGESPOLBKDM4E | |
| SCHEMBL4654782 | 0.83 | ALOX5 (0.49) | NR1H4ALOX5PTGESPOLBKDM4E | |
| SCHEMBL4625145 | 0.81 | ALOX5 (0.61) | NR1H4ALOX5PTGESPOLBGAA | |
| SCHEMBL8300058 | 0.80 | ALOX5 (0.50) | ALOX5PTGESPOLBKDM4EGAA | |
| SCHEMBL5560476 | 0.80 | ALOX5 (0.57) | ALOX5PTGESPOLBGAAALDH1A1 | |
| SCHEMBL4625346 | 0.80 | ALOX5 (0.64) | ALOX5PTGESPOLBKDM4EGAA | |
| SCHEMBL14586194 | 0.80 | ALOX5 (0.57) | ALOX5PTGESPOLBKDM4EGAA | |
| SCHEMBL8298566 | 0.79 | ALOX5 (0.64) | ALOX5PTGESKDM4EGAATDP1 | |
| SCHEMBL4625153 | 0.79 | ALOX5 (0.64) | ALOX5PTGESKDM4EGAATDP1 | |
| SCHEMBL4625225 | 0.78 | ALOX5 (0.58) | ALOX5PTGESPOLBKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183267-B2 | β-lactamase inhibitors and methods of use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183267-B2 | β-lactamase inhibitors and methods of use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-02-27 | — | — | US | disclosed |
| WO-2005041904-A2 | INHIBITORS OF CORONAVIRUS PROTEASE AND METHODS OF USE THEREOF | FULCRUM PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |