Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 20/20 | 0.59 |
| ▸ | TACR2 | P21452 | 2/20 | 0.51 |
| ▸ | TACR3 | P29371 | 2/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817874 | 0.95 | TACR1 (0.54) | TACR1 | |
| SCHEMBL7846541 | 0.95 | TACR1 (0.60) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL7956549 | 0.91 | TACR1 (0.49) | TACR1CCR5 | |
| SCHEMBL4630790 | 0.86 | TACR1 (0.44) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8589071 | 0.86 | TACR1 (0.52) | TACR1TACR2TACR3 | |
| SCHEMBL8970672 | 0.86 | TACR1 (0.47) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8484370 | 0.86 | TACR1 (0.50) | TACR1TACR2 | |
| SCHEMBL7811978 | 0.84 | TACR2 (0.62) | TACR1TACR2 | |
| SCHEMBL8567221 | 0.83 | TACR1 (0.51) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL7765734 | 0.82 | TACR1 (0.40) | TACR1TACR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512901-B1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-06-23 | — | — | EP | disclosed |
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0512901-A1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |