Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8294465 | 0.87 | ALDH1A1 (0.42) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL26529163 | 0.84 | ALDH1A1 (0.40) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL9366080 | 0.80 | ALDH1A1 (0.43) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL26529162 | 0.78 | MAPT (0.47) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL30503607 | 0.74 | MAPT (0.47) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL9452622 | 0.74 | MAPT (0.47) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL6478476 | 0.74 | HTR2A (0.44) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL28268627 | 0.74 | ALDH1A1 (0.61) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL7117117 | 0.73 | TDP1 (0.50) | ALDH1A1CYP3A4MAPTTDP1MEN1 | |
| SCHEMBL10939007 | 0.72 | ALDH1A1 (0.54) | ALDH1A1CYP3A4MAPTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785932-B1 | PYRROLYL TETRAHYDROBENZOQUINOXALINE DIONES, THEIR PREPARATION AND USE AS GLUTAMATE RECEPTOR ANTAGONISTS | BASF AG (DE) | 1999-12-29 | — | — | EP | disclosed |
| US-5849744-A | Pyrrolyl tetrahydrobenzoquinoxaline diones, their preparation and use as glutamate receptor antagonist | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| EP-0785932-A1 | PYRROLYL TETRAHYDROBENZOQUINOXALINE DIONES, THEIR PREPARATION AND USE AS GLUTAMATE RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011922-A1 | PYRROLYL TETRAHYDROBENZOQUINOXALINE DIONES, THEIR PREPARATION AND USE AS GLUTAMATE RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1996-04-25 | — | — | WO | disclosed |