SCHEMBL8301141

SCHEMBL8301141

N#Cc1ccc(Cl)c(Oc2ccc(C(F)(F)F)cn2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.61
L3MBTL1 Q9Y468 2/20 0.53
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
POLB P06746 2/20 0.45
LMNA P02545 2/20 0.45
MEN1 O00255 1/20 0.45
TSHR P16473 1/20 0.44
MRGPRX4 Q96LA9 1/20 0.44
MAPT P10636 2/20 0.43
THRB P10828 1/20 0.42
MAPK1 P28482 1/20 0.41
SLC22A12 Q96S37 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
KIF11 P52732 1/20 0.39
CNR1 P21554 2/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CNR2 P34972 1/20 0.38
KCNH2 Q12809 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8304647 0.90 KMT2A (0.61) KMT2AL3MBTL1HPGDSMN1; SMN2POLB
SCHEMBL8299427 0.85 HPGD (0.49) KMT2AL3MBTL1HPGDSMN1; SMN2POLB
SCHEMBL8304006 0.84 SMN1; SMN2 (0.55) KMT2AL3MBTL1HPGDSMN1; SMN2POLB
SCHEMBL8300459 0.84 SMN1; SMN2 (0.55) KMT2AL3MBTL1HPGDSMN1; SMN2POLB
SCHEMBL24401108 0.81 KMT2A (0.50) KMT2AL3MBTL1HPGDSMN1; SMN2POLB
SCHEMBL1011521 0.80 KMT2A (0.66) KMT2AL3MBTL1HPGDSMN1; SMN2POLB
SCHEMBL6982061 0.78 MAPT (0.57) KMT2ASMN1; SMN2LMNATSHRMAPT
SCHEMBL1011001 0.77 KMT2A (0.61) KMT2AL3MBTL1HPGDSMN1; SMN2POLB
SCHEMBL30731743 0.76 MAPK1 (0.62) KMT2AL3MBTL1HPGDSMN1; SMN2POLB
SCHEMBL24664166 0.76 MAPK1 (0.62) KMT2AL3MBTL1HPGDSMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648752-B1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-10-06 EP disclosed
US-5700824-A Triazole derivatives, insecticide, acaricide and methods thereof KUMIAI CHEMICAL INDUSTRIAL CO. LTD. (JP) 1997-12-23 US disclosed
US-5616594-A Triazole derivatives, insecticide, acaricide and methods thereof IHARA CHEMICAL INDUSTRY CO. LTD. (JP) 1997-04-01 US disclosed
EP-0648752-A1 TRIAZOLE DERIVATIVE, INSECTICIDAL/ACARICIDAL AGENT, AND PROCESS FOR PRODUCING THE SAME KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-04-19 EP disclosed