Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30731743 | 1.00 | MAPK1 (0.62) | MAPK1THRBL3MBTL1ALDH1A1POLB | |
| SCHEMBL6982061 | 0.83 | MAPT (0.57) | MAPK1THRBTSHRSMN1; SMN2KMT2A | |
| SCHEMBL24401108 | 0.80 | KMT2A (0.50) | MAPK1THRBL3MBTL1POLBTSHR | |
| SCHEMBL10500983 | 0.79 | MAPK1 (0.67) | MAPK1THRBL3MBTL1ALDH1A1POLB | |
| SCHEMBL20381754 | 0.79 | MAPK1 (0.71) | MAPK1THRBL3MBTL1ALDH1A1POLB | |
| SCHEMBL5651111 | 0.79 | MAPK1 (0.67) | MAPK1THRBL3MBTL1ALDH1A1POLB | |
| SCHEMBL1011398 | 0.79 | THRB (0.72) | MAPK1THRBL3MBTL1ALDH1A1POLB | |
| SCHEMBL3287232 | 0.79 | MAP4K4 (0.50) | ALDH1A1MAP4K4KMT2AHRH3KCNH2 | |
| SCHEMBL30334879 | 0.79 | MAPK1 (0.67) | MAPK1THRBL3MBTL1ALDH1A1POLB | |
| SCHEMBL29123563 | 0.79 | MAP4K4 (0.53) | MAPK1ALDH1A1MAP4K4KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117015537-A | Heteroaryl aminopropanol derivatives as inhibitors of LTA4H | 诺华股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |