Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 4/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL136136 | 0.82 | LMNA (0.38) | CYP2C19HIF1AALDH1A1CHRM3KCNN4 | |
| SCHEMBL2338549 | 0.76 | CYP2C19 (0.47) | CYP2C19HIF1AALDH1A1MAPTCHRM3 | |
| SCHEMBL2338554 | 0.76 | CYP2C19 (0.47) | CYP2C19HIF1AALDH1A1MAPTCHRM3 | |
| SCHEMBL29288247 | 0.75 | KCNN4 (0.41) | CYP2C19HIF1AMAPTCHRM3KCNN4 | |
| SCHEMBL13387222 | 0.75 | TSHR (0.49) | CYP2C19HIF1AALDH1A1CHRM3SMN1; SMN2 | |
| SCHEMBL9651868 | 0.72 | CNR1 (0.40) | CHRM3CHRM2CHRM1KIF11 | |
| SCHEMBL13346886 | 0.70 | CYP2C19 (0.46) | CYP2C19HIF1AALDH1A1MAPTCHRM3 | |
| SCHEMBL9207734 | 0.69 | KCNN4 (0.36) | CYP2C19HIF1AALDH1A1CHRM3KCNN4 | |
| SCHEMBL895242 | 0.69 | KCNN4 (0.36) | CYP2C19HIF1AALDH1A1MAPTCHRM3 | |
| SCHEMBL9371117 | 0.68 | EBP (0.39) | ALDH1A1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479431-B1 | Intermediates to 1-carbacephalosporins and process for preparation thereof | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1996005828-A1 | PYRROLIDINYL DI-CARBOXYLIC ACID DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-02-29 | — | — | WO | disclosed |
| US-5225553-A | Intermediates to 1-carbacephalosporins and process for preparation thereof | ELI LILLY AND COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5159073-A | Intermediates to 1-carbacephalosporins and process for preparation thereof | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0494733-A1 | Trifluoromethyl 1-carba(1-dethia)cephems | ELI LILLY AND COMPANY (US) | 1992-07-15 | — | — | EP | disclosed |
| EP-0479431-A1 | Intermediates to 1-carbacephalosporins and process for preparation thereof | ELI LILLY AND COMPANY (US) | 1992-04-08 | — | — | EP | disclosed |