Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5018075 | 0.90 | NPC1 (0.55) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL8302112 | 0.89 | NPC1 (0.46) | NPC1RAB9AMAPTSMN1; SMN2TSHR | |
| SCHEMBL8301459 | 0.89 | PDE4B (0.53) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL8300121 | 0.87 | PDE4B (0.47) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL8298185 | 0.85 | PDE4A (0.46) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL8298189 | 0.82 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5018001 | 0.80 | LRRK2 (0.51) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL5023240 | 0.78 | PDE4B (0.63) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL3995780 | 0.78 | KMT2A (0.46) | MAPTSMN1; SMN2KDM4ETSHRGAA | |
| SCHEMBL4034779 | 0.78 | GAA (0.53) | NPC1RAB9AMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111044-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS:PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-12-23 | — | — | WO | disclosed |