Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023240 | 0.89 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3995780 | 0.89 | KMT2A (0.46) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL8301499 | 0.89 | NPC1 (0.46) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL8298298 | 0.87 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL8298275 | 0.84 | CYP19A1 (0.47) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL8298189 | 0.82 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL14161809 | 0.79 | LMNA (0.42) | LMNAMAPK1HTTMAPTPTGS2 | |
| SCHEMBL5016460 | 0.79 | LMNA (0.51) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL8302112 | 0.78 | NPC1 (0.46) | MAPK1MAPTSMN1; SMN2POLBCYP19A1 | |
| SCHEMBL14364592 | 0.78 | RXFP1 (0.54) | PDE4BPDE4APDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111044-A1 | TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS:PROCESS FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-12-23 | — | — | WO | disclosed |