Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31317790 | 0.86 | POLB (0.70) | SMN1; SMN2POLBALDH1A1KMT2ARAB9A | |
| SCHEMBL4191490 | 0.86 | POLB (0.70) | SMN1; SMN2POLBALDH1A1KMT2ARAB9A | |
| SCHEMBL4823240 | 0.85 | HPGD (0.68) | SMN1; SMN2LMNANPSR1POLBALDH1A1 | |
| SCHEMBL3560486 | 0.85 | POLB (0.73) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL134028 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNANPSR1POLBALDH1A1 | |
| SCHEMBL134279 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNANPSR1POLBALDH1A1 | |
| SCHEMBL27183334 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNANPSR1POLBALDH1A1 | |
| SCHEMBL856142 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL396078 | 0.80 | NPSR1 (0.62) | SMN1; SMN2LMNANPSR1POLBALDH1A1 | |
| SCHEMBL1726857 | 0.80 | LMNA (0.76) | SMN1; SMN2LMNAPOLBKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651641-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2005009995-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |