Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14614862 | 0.91 | MEN1 (0.44) | MEN1KMT2AHPGDALDH1A1KDM4C | |
| SCHEMBL8296601 | 0.89 | MEN1 (0.54) | MEN1KMT2ADRD4HPGDALDH1A1 | |
| SCHEMBL14536598 | 0.87 | MEN1 (0.47) | MEN1KMT2AHPGDALDH1A1KDM4C | |
| SCHEMBL8297695 | 0.86 | MEN1 (0.46) | MEN1KMT2ADRD4HPGDALDH1A1 | |
| SCHEMBL14615145 | 0.84 | KMT2A (0.47) | MEN1KMT2AALDH1A1KDM4CL3MBTL1 | |
| SCHEMBL8296597 | 0.82 | MEN1 (0.51) | MEN1KMT2AHPGDALDH1A1KDM4C | |
| SCHEMBL8299855 | 0.80 | MEN1 (0.44) | MEN1KMT2AHPGDALDH1A1KDM4C | |
| SCHEMBL8297703 | 0.80 | NPC1 (0.44) | MEN1KMT2AHPGDALDH1A1NPC1 | |
| SCHEMBL8301720 | 0.78 | MEN1 (0.44) | MEN1KMT2AKDM4CNPC1RAB9A | |
| SCHEMBL19175392 | 0.77 | KDM4C (0.43) | MEN1KMT2AHPGDALDH1A1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651641-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-05-23 | — | — | EP | disclosed |
| EP-1651640-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005009995-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |