Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302809 | 0.89 | KMT2A (0.51) | MEN1KMT2AKDM4CCCNA2CDK2 | |
| SCHEMBL8299866 | 0.87 | MEN1 (0.47) | MEN1KMT2AKDM4CGAAMAPT | |
| SCHEMBL8297699 | 0.86 | MEN1 (0.43) | MEN1KMT2AKDM4CCCNA2CDK2 | |
| SCHEMBL14615145 | 0.82 | KMT2A (0.47) | MEN1KMT2AKDM4CL3MBTL1 | |
| SCHEMBL14614862 | 0.78 | MEN1 (0.44) | MEN1KMT2AKDM4CMAPTL3MBTL1 | |
| SCHEMBL8301772 | 0.78 | MEN1 (0.47) | MEN1KMT2AKDM4CMAPTL3MBTL1 | |
| SCHEMBL8296596 | 0.76 | MEN1 (0.51) | MEN1KMT2AKDM4CMAPTL3MBTL1 | |
| SCHEMBL21818634 | 0.76 | KMT2A (0.51) | MEN1KMT2AKDM4CL3MBTL1NPC1 | |
| SCHEMBL8296603 | 0.76 | MEN1 (0.54) | MEN1KMT2AKDM4CGAANPC1 | |
| SCHEMBL8299855 | 0.74 | MEN1 (0.44) | MEN1KMT2AKDM4CMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651641-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-05-23 | — | — | EP | disclosed |
| EP-1651640-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005009995-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |