Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 9/20 | 0.73 |
| ▸ | MMP13 | P45452 | 3/20 | 0.73 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141861 | 0.87 | MMP12 (0.64) | MMP12MMP13EPHX1EPHX2MMP3 | |
| SCHEMBL6141848 | 0.85 | MMP12 (1.00) | MMP12MMP13EPHX1MMP3MMP9 | |
| SCHEMBL6141835 | 0.85 | MMP12 (1.00) | MMP12MMP13EPHX1MMP3MMP9 | |
| SCHEMBL6368500 | 0.85 | MMP12 (1.00) | MMP12MMP13EPHX1MMP3MMP9 | |
| SCHEMBL6452240 | 0.84 | MMP12 (0.60) | MMP12MMP13EPHX1EPHX2TRPV1 | |
| SCHEMBL8301905 | 0.80 | MMP12 (0.78) | MMP12MMP13EPHX2MMP3MMP9 | |
| SCHEMBL6454253 | 0.79 | MMP12 (0.62) | MMP12MMP13EPHX1EPHX2TRPV1 | |
| SCHEMBL6367993 | 0.77 | MMP12 (0.73) | MMP12MMP13EPHX1MMP3MMP9 | |
| SCHEMBL6367899 | 0.76 | MMP12 (0.73) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6530795 | 0.76 | MMP12 (0.58) | MMP12MMP13EPHX1EPHX2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003115-A1 | THIOPHENE AMINO ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |