Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 9/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8388837 | 0.98 | TSHR (0.36) | TSHRTDP1CASP1MAPTCACNA1B | |
| SCHEMBL18159719 | 0.79 | TDP1 (0.39) | TSHRTDP1CASP1MAPTCACNA1B | |
| SCHEMBL5061936 | 0.77 | ALDH1A1 (0.50) | CASP1ALDH1A1MEN1KMT2A | |
| SCHEMBL16863787 | 0.77 | ALDH1A1 (0.50) | CASP1ALDH1A1MEN1KMT2A | |
| SCHEMBL5062025 | 0.77 | ALDH1A1 (0.50) | CASP1ALDH1A1MEN1KMT2A | |
| SCHEMBL13604074 | 0.76 | TSHR (0.38) | TSHRTDP1SMN1; SMN2 | |
| SCHEMBL7050671 | 0.76 | TSHR (0.48) | TSHRTDP1ALDH1A1 | |
| SCHEMBL25855372 | 0.75 | TDP1 (0.41) | TSHRTDP1CASP1MAPTCACNA1B | |
| Hydrochloric Acid SCHEMBL3813206 | 0.75 | TSHR (0.37) | TSHRTDP1SMN1; SMN2 | |
| SCHEMBL1282757 | 0.75 | TSHR (0.45) | TSHRTDP1CASP1MAPTCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996039137-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |