Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 5/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646019 | 0.92 | FGFR1 (0.49) | BRD4ATRFLT3FGFR1FGFR2 | |
| SCHEMBL8302860 | 0.92 | ATR (0.46) | BRD4ATRFLT3FGFR1FGFR2 | |
| SCHEMBL13446029 | 0.90 | ATR (0.43) | BRD4ATRFLT3FGFR1FGFR2 | |
| SCHEMBL13446030 | 0.89 | ATR (0.44) | BRD4ATRFLT3FGFR1FGFR2 | |
| SCHEMBL13446028 | 0.88 | FGFR1 (0.47) | BRD4ATRFLT3FGFR1FGFR2 | |
| SCHEMBL1645356 | 0.87 | ATR (0.43) | BRD4ATRFLT3FGFR1FGFR2 | |
| SCHEMBL13544986 | 0.87 | FGFR1 (0.48) | BRD4ATRFLT3FGFR1FGFR2 | |
| SCHEMBL1646399 | 0.85 | ATR (0.44) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL13544987 | 0.85 | RAB9A (0.44) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL1646675 | 0.85 | BRD4 (0.42) | BRD4ATRFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002552-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |