Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.60 |
| ▸ | DRD4 | P21917 | 7/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.60 |
| ▸ | HTR7 | P34969 | 3/20 | 0.60 |
| ▸ | HTR2B | P41595 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5584754 | 0.95 | HTR1A (0.61) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8297143 | 0.95 | HTR1A (0.61) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8297142 | 0.95 | HTR1A (0.61) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8299047 | 0.88 | HTR1A (0.57) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8296092 | 0.86 | HTR1A (0.59) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8302508 | 0.83 | HTR1A (0.57) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8299009 | 0.83 | HTR1A (0.57) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8302029 | 0.83 | HTR1A (0.64) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8298210 | 0.82 | HTR1A (0.64) | HTR1ADRD4ADRA1AADRA1BHTR7 | |
| SCHEMBL8296419 | 0.82 | HTR1A (0.63) | HTR1ADRD4ADRA1AADRA1BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |