Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | CLK1 | P49759 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421985 | 0.80 | KDM4E (0.43) | NR3C1NR3C2DYRK1ACLK1CLK2 | |
| SCHEMBL29361472 | 0.79 | TSHR (0.41) | NR3C1NR3C2DYRK1ACLK1KDM4E | |
| SCHEMBL15451009 | 0.79 | TSHR (0.41) | NR3C1NR3C2DYRK1ACLK1KDM4E | |
| SCHEMBL12778112 | 0.77 | DYRK1A (0.41) | NR3C1NR3C2DYRK1ACLK1KDM4E | |
| SCHEMBL26670773 | 0.75 | GAA (0.46) | NR3C1NR3C2KDM4EGAAALDH1A1 | |
| SCHEMBL7848657 | 0.75 | NR3C1 (0.38) | NR3C1NR3C2DYRK1ACLK1KDM4E | |
| SCHEMBL23676495 | 0.75 | DYRK1A (0.36) | NR3C1NR3C2DYRK1ACLK1KDM4E | |
| SCHEMBL12755314 | 0.75 | NR3C1 (0.39) | NR3C1NR3C2DYRK1ACLK1CLK2 | |
| SCHEMBL27336454 | 0.75 | NR3C1 (0.43) | NR3C1NR3C2DYRK1ACLK1KDM4E | |
| SCHEMBL23660457 | 0.71 | CYP2A6 (0.47) | NR3C1NR3C2DYRK1ACLK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469833-B1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY CO ELI (GB) | 1999-09-08 | — | — | EP | disclosed |
| US-5281593-A | Pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1994-01-25 | — | — | US | disclosed |
| EP-0469833-A1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |