Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 9/20 | 0.69 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.56 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | GUSB | P08236 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303422 | 1.00 | GPR132 (0.69) | GPR132SMPD1NR4A2NR1H4MAOB | |
| SCHEMBL27658913 | 0.85 | GPR132 (0.65) | GPR132SMPD1NR4A2NR1H4MAOB | |
| SCHEMBL15232861 | 0.85 | KMT2A (0.59) | GPR132SMPD1NR4A2MAOBPTPN1 | |
| SCHEMBL27658918 | 0.84 | GPR132 (0.64) | GPR132SMPD1NR4A2NR1H4MAOB | |
| SCHEMBL13702183 | 0.83 | GPR132 (0.73) | GPR132SMPD1NR4A2NR1H4MAOB | |
| SCHEMBL14005611 | 0.83 | GPR132 (0.72) | GPR132SMPD1NR4A2NR1H4MAOB | |
| SCHEMBL27658922 | 0.83 | GPR132 (0.62) | GPR132SMPD1NR4A2NR1H4MAOB | |
| SCHEMBL1123133 | 0.82 | GPR132 (0.77) | GPR132SMPD1NR4A2NR1H4MAOB | |
| SCHEMBL1123022 | 0.81 | GPR132 (0.75) | GPR132SMPD1NR4A2NR1H4MAOB | |
| SCHEMBL4893620 | 0.81 | GPR132 (0.69) | GPR132SMPD1NR4A2NR1H4MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5814648-A | N-hydroxyureas as antiinflammatory agents | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |