Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8576888 | 0.88 | PTGS2 (0.49) | PTGS2IDO1PTGS1 | |
| SCHEMBL8303948 | 0.85 | PTGS2 (0.59) | PTGS2PTGS1HAO1 | |
| SCHEMBL3000770 | 0.83 | HAO1 (0.56) | PTGS2PTGS1ALOX5APPHAO1 | |
| SCHEMBL12091881 | 0.82 | APP (0.46) | PTGS2PTGS1ALOX5APPCA12 | |
| SCHEMBL8310335 | 0.82 | PTGS2 (0.59) | PTGS2PTGS1APP | |
| SCHEMBL8308575 | 0.81 | PTGS2 (0.68) | PTGS2PTGS1HAO1 | |
| SCHEMBL8308253 | 0.81 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL8570396 | 0.80 | PTGS2 (0.60) | PTGS2IDO1PTGS1 | |
| SCHEMBL8304224 | 0.79 | PTGS2 (0.52) | PTGS2PTGS1APPHAO1 | |
| SCHEMBL8444527 | 0.79 | PTGS2 (0.52) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915848-A1 | 1,2-DIARYLINDOLE AS COX-2 INHIBITORS | LABORATOIRES UPSA (FR) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998005639-A1 | 1,2-DIARYLINDOLE AS COX-2 INHIBITORS | LABORATOIRES UPSA (FR) | 1998-02-12 | — | — | WO | disclosed |