Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 3/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7499272 | 0.99 | KDM4E (0.33) | KDM4EALDH1A1CYP2C9CYP2C19MGLL | |
| Hydrochloric Acid SCHEMBL8186905 | 0.94 | KDM4E (0.32) | KDM4EALDH1A1CYP2C9CYP2C19MGLL | |
| Citric Acid SCHEMBL8188402 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL8188711 | 0.93 | KDM4E (0.32) | KDM4EALDH1A1CCR3ORAI1 | |
| SCHEMBL7494164 | 0.93 | KDM4E (0.35) | KDM4EALDH1A1CYP2C9CYP2C19MGLL | |
| Hydrochloric Acid SCHEMBL8186493 | 0.92 | KDM4E (0.32) | KDM4EALDH1A1CCR3ORAI1 | |
| Hydrochloric Acid SCHEMBL7498615 | 0.92 | KDM4E (0.34) | KDM4EALDH1A1CYP2C9CYP2C19MGLL | |
| Hydrochloric Acid SCHEMBL8188451 | 0.92 | DRD2 (0.35) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8048899 | 0.89 | KDM4E (0.31) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8176848 | 0.89 | KDM4E (0.31) | KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11106375-A | — | — | None | — | — | JP | disclosed |
| JP-H11106375-A | OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE COMPOUND AS BRADYKININ ANTAGONIST | PFIZER PHARMACEUT INC | 1999-04-20 | — | — | JP | disclosed |
| EP-0899261-A1 | Optical active 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 1999-03-03 | — | — | EP | disclosed |