Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15312720 | 0.98 | EPHX1 (0.41) | EPHX1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1954999 | 0.88 | EPHX1 (0.42) | EPHX1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL3685791 | 0.86 | EPHX1 (0.41) | EPHX1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4722846 | 0.84 | ALDH1A1 (0.41) | EPHX1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1952344 | 0.83 | EPHX1 (0.49) | EPHX1SMN1; SMN2ACHEMAPK1 | |
| SCHEMBL1954820 | 0.82 | EPHX1 (0.51) | EPHX1SMN1; SMN2ACHEMAPK1 | |
| SCHEMBL1954712 | 0.82 | EPHX1 (0.51) | EPHX1SMN1; SMN2ACHEMAPK1 | |
| SCHEMBL1955076 | 0.82 | EPHX1 (0.51) | EPHX1SMN1; SMN2ACHEMAPK1 | |
| SCHEMBL1952005 | 0.82 | EPHX1 (0.51) | EPHX1SMN1; SMN2ACHEMAPK1 | |
| SCHEMBL1953898 | 0.82 | EPHX1 (0.51) | EPHX1SMN1; SMN2ACHEMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835109-A4 | PYRIDINONE-THROMBIN INHIBITORS | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| EP-0835109-A1 | PYRIDINONE-THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 1998-04-15 | — | — | EP | disclosed |