Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28412023 | 0.77 | GRM5 (0.35) | GRM5 | |
| SCHEMBL19578703 | 0.76 | GRM5 (0.39) | GRM5NOS1CHRM2CHRM1CA12 | |
| SCHEMBL104471 | 0.76 | FFAR1 (0.40) | GRM5CHRM2CHRM1 | |
| SCHEMBL6786135 | 0.76 | ALDH1A1 (0.38) | GRM5NOS1CHRM2CHRM1CA12 | |
| SCHEMBL1067293 | 0.72 | GRM5 (0.41) | GRM5CHRM2CHRM1CA12CA1 | |
| SCHEMBL5894329 | 0.71 | IDO1 (0.35) | — | |
| SCHEMBL24286742 | 0.67 | GRM5 (0.38) | GRM5CA12CA1CA9 | |
| SCHEMBL21727247 | 0.67 | GRM5 (0.38) | GRM5CA12CA1CA9 | |
| SCHEMBL8005775 | 0.67 | GRM5 (0.42) | GRM5CA12CA1CA9 | |
| SCHEMBL6508646 | 0.67 | APP (0.48) | CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749430-B1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PROD (US) | 1999-08-25 | — | — | EP | disclosed |
| US-5605918-A | SUBSTITUTED THIAZOLIDINE-2,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| WO-1995024400-A1 | THIAZOLIDINEDIONE DERIVATIVES AS ANTI-HYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-14 | — | — | WO | disclosed |