Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304089 | 1.00 | NPC1 (0.62) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1298504 | 0.89 | NPC1 (0.70) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14352146 | 0.89 | NPC1 (0.70) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13495018 | 0.84 | NPC1 (0.71) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1149438 | 0.84 | NPC1 (0.71) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29938562 | 0.84 | NPC1 (0.71) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9614459 | 0.82 | NPC1 (0.61) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8304084 | 0.82 | NPC1 (0.62) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8308063 | 0.82 | NPC1 (0.62) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8307476 | 0.82 | NPC1 (0.62) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5814648-A | N-hydroxyureas as antiinflammatory agents | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |