Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.80 |
| ▸ | HTR1B | P28222 | 12/20 | 0.80 |
| ▸ | HTR2A | P28223 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | THPO | P40225 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302018 | 0.92 | HTR1D (0.82) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL6603417 | 0.89 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL6603418 | 0.89 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL6603530 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL6603527 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL6928454 | 0.81 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8792752 | 0.78 | HTR1D (0.66) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL7830477 | 0.78 | HTR1D (0.86) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL5432776 | 0.77 | HTR1D (0.91) | HTR1DHTR1BHTR2AMAPTMEN1 | |
| SCHEMBL8641925 | 0.76 | HTR1D (0.65) | HTR1DHTR1BHTR2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716650-B1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-24 | — | — | EP | claimed |
| EP-0716650-B1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-24 | — | — | EP | disclosed |
| US-5696122-A | Indole and indoline derivatives as 5HT1D receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-09 | — | — | US | disclosed |
| EP-0716650-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-19 | — | — | EP | disclosed |
| WO-1995006637-A1 | INDOLE AND INDOLINE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-03-09 | — | — | WO | disclosed |