Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 16/20 | 0.65 |
| ▸ | HTR1B | P28222 | 14/20 | 0.65 |
| ▸ | HTR2A | P28223 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | THPO | P40225 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426990 | 0.80 | HTR1D (0.66) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL5432776 | 0.80 | HTR1D (0.91) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8536581 | 0.79 | HTR1D (0.67) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8302018 | 0.79 | HTR1D (0.82) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL6603530 | 0.79 | HTR1D (1.00) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL6603527 | 0.79 | HTR1D (1.00) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8389415 | 0.79 | HTR1D (0.72) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8792752 | 0.78 | HTR1D (0.66) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8304096 | 0.76 | HTR1D (0.80) | HTR1DHTR1BHTR2AMEN1MAPT | |
| Oxalic Acid SCHEMBL6924129 | 0.76 | HTR1D (0.86) | HTR1DHTR1BHTR2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819126-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031508-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-10 | — | — | WO | disclosed |