Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.47 |
| ▸ | PDE4A | P27815 | 6/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303942 | 0.85 | PDE3B (0.42) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10405611 | 0.85 | NR1H2 (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8110725 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2NR1H2 | |
| SCHEMBL8306283 | 0.84 | LMNA (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10405646 | 0.83 | NR1H2 (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10406380 | 0.82 | TBXA2R (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10405732 | 0.82 | NR1H2 (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10405750 | 0.82 | PDE4B (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8303551 | 0.81 | LMNA (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10406144 | 0.81 | NR1H2 (0.53) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6073020-A | — | — | None | — | — | JP | disclosed |
| JP-7233072-A | — | — | None | — | — | JP | disclosed |
| EP-0579059-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| JP-H07233072-A | MEDICINE COMPOSITION | TANABE SEIYAKU CO LTD | 1995-09-05 | — | — | JP | disclosed |
| JP-H0673020-A | PYRIDAZINONE DERIVATIVE AND ITS PRODUCTION | TANABE SEIYAKU CO LTD | 1994-03-15 | — | — | JP | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |
| JP-H00673020-A | — | — | 0001-01-01 | — | — | JP | disclosed |