Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 3/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583956 | 0.92 | MAPK14 (0.57) | CSNK1DCSNK1A1RPS6KA3MAPK14JAK3 | |
| SCHEMBL4584925 | 0.80 | MAPK14 (0.61) | CSNK1DCSNK1A1RPS6KA3MAPK14JAK3 | |
| SCHEMBL4585060 | 0.79 | MAPK14 (0.60) | CSNK1DCSNK1A1RPS6KA3MAPK14JAK3 | |
| SCHEMBL6950701 | 0.79 | MAPK14 (0.60) | CSNK1DCSNK1A1RPS6KA3MAPK14JAK3 | |
| SCHEMBL4585443 | 0.78 | MAPK14 (0.57) | CSNK1DCSNK1A1RPS6KA3MAPK14JAK3 | |
| SCHEMBL4584826 | 0.76 | CSNK1D (0.50) | CSNK1DCSNK1A1RPS6KA3MAPK14JAK3 | |
| SCHEMBL4585063 | 0.76 | MAPK14 (0.58) | CSNK1DCSNK1A1RPS6KA3MAPK14MAPK13 | |
| SCHEMBL4585062 | 0.76 | MAPK14 (0.50) | CSNK1DCSNK1A1RPS6KA3MAPK14MAPK13 | |
| SCHEMBL4583203 | 0.74 | MAPK14 (0.52) | CSNK1DCSNK1A1RPS6KA3MAPK14MAPK13 | |
| SCHEMBL4915940 | 0.73 | MAPK14 (0.73) | CSNK1DCSNK1A1MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889726-A4 | NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 1999-07-21 | — | — | EP | claimed |
| EP-0889726-A1 | NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997025048-A1 | NOVEL CYCLOALKYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | claimed |