Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13315848 | 0.87 | SMN1; SMN2 (0.56) | TSHRPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8305122 | 0.82 | CYP2C19 (0.56) | TSHRPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9121424 | 0.80 | POLB (0.60) | TSHRPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4461404 | 0.78 | SMN1; SMN2 (0.51) | TSHRPOLBSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL17633946 | 0.77 | TSHR (0.50) | TSHRPOLBMAPTSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8763040 | 0.77 | SMN1; SMN2 (0.50) | TSHRPOLBSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL236205 | 0.76 | HPGD (0.56) | POLBMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL14345662 | 0.76 | POLB (0.55) | TSHRPOLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2222434 | 0.76 | SMN1; SMN2 (0.60) | TSHRPOLBSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8895881 | 0.76 | CYP2C19 (0.66) | MAPTSMN1; SMN2ALDH1A1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0583421-B1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1999-06-16 | — | — | EP | disclosed |
| EP-0512400-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 1998-12-02 | — | — | EP | disclosed |
| US-5576315-A | Substituted dibenzoxazepine compounds and methods for treating osteoporosis and ischemia | G.D. SEARLE & CO. (US) | 1996-11-19 | — | — | US | disclosed |
| US-5464830-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5382578-A | Anticonvulsants or antiischemic agents | G. D. SEARLE & CO. (US) | 1995-01-17 | — | — | US | disclosed |
| US-5378840-A | Substituted dibenzoxazepine compounds | G. D. SEARLE & CO. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0610303-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS AS ANALGESIC AGENTS | G.D. SEARLE & CO. (US) | 1994-08-17 | — | — | EP | disclosed |
| EP-0583421-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-02-23 | — | — | EP | disclosed |
| US-5288719-A | 2-,3-,8-and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating osteoporosis | G. D. SEARLE & CO. (US) | 1994-02-22 | — | — | US | disclosed |
| US-5212169-A | Analgesics | G. D. SEARLE & CO. (US) | 1993-05-18 | — | — | US | disclosed |
| WO-1993009105-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS AS ANALGESIC AGENTS | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | disclosed |
| EP-0539977-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ANALGESIC AGENTS AND PROSTAGLANDIN ANTAGONISTS | G.D. Searle & Co. (US) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992019617-A2 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512400-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |