Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.52 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27867853 | 0.87 | DPP4 (0.52) | DPP4NOS3NOS1NOS2APP | |
| SCHEMBL9294904 | 0.84 | DPP4 (0.57) | DPP4NOS3NOS1NOS2HSD17B3 | |
| SCHEMBL3785259 | 0.84 | DPP4 (0.57) | DPP4NOS3NOS1NOS2HSD17B3 | |
| SCHEMBL5045191 | 0.81 | DPP4 (0.57) | DPP4NOS3NOS1NOS2HSD17B3 | |
| SCHEMBL1007616 | 0.78 | MCL1 (0.59) | APPTSHRCASP1MCL1HTR7 | |
| SCHEMBL27470047 | 0.77 | APP (0.57) | APPTSHRCASP1MCL1MAPT | |
| SCHEMBL12524048 | 0.74 | DPP4 (0.69) | DPP4NOS3NOS1NOS2PNMT | |
| SCHEMBL1038044 | 0.74 | DPP4 (0.69) | DPP4NOS3NOS1NOS2HTR7 | |
| SCHEMBL3787422 | 0.74 | DPP4 (0.62) | DPP4NOS3NOS1NOS2HTR7 | |
| SCHEMBL2450381 | 0.74 | DPP4 (0.62) | DPP4NOS3NOS1NOS2PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |