SCHEMBL8304666

SCHEMBL8304666

O=CNC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1

nearest known ligand 0.72

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 12/20 0.72
MAOA P21397 5/20 0.72
PTGS1 P23219 2/20 0.72
SDHA P31040 2/20 0.72
LMNA P02545 1/20 0.72
CALML3 P27482 1/20 0.72
F10 P00742 7/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8304669 1.00 MAOB (0.72) MAOBMAOAPTGS1SDHALMNA
SCHEMBL15142008 0.91 MAOB (0.77) MAOBMAOAPTGS1SDHALMNA
SCHEMBL6040418 0.91 MAOB (0.71) MAOBMAOAPTGS1SDHALMNA
SCHEMBL6040427 0.91 MAOB (0.71) MAOBMAOAPTGS1SDHALMNA
SCHEMBL6914676 0.88 MAOB (0.76) MAOBMAOAPTGS1SDHALMNA
SCHEMBL14611817 0.88 MAOB (0.75) MAOBMAOAPTGS1SDHALMNA
SCHEMBL19827260 0.88 MAOB (0.72) MAOBMAOAPTGS1SDHALMNA
SCHEMBL23699721 0.87 MAOB (0.78) MAOBMAOAPTGS1SDHALMNA
SCHEMBL15444679 0.87 MAOB (0.74) MAOBMAOAPTGS1SDHALMNA
SCHEMBL23699719 0.87 MAOB (0.78) MAOBMAOAPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0717738-B1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS UPJOHN CO (US) 1999-10-20 EP claimed
US-20090247545-A1 SUBSTITUTED OXAZOLIDINONE DERIVATIVES RANBAXY LABORATORIES LIMITED (IN) 2009-10-01 US disclosed
US-20090247545-A1 SUBSTITUTED OXAZOLIDINONE DERIVATIVES RANBAXY LABORATORIES LIMITED (IN) 2009-10-01 US disclosed
WO-2008106225-A1 MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME RIB-X PHARMACEUTICALS, INC. (US) 2008-09-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247545-A1 SUBSTITUTED OXAZOLIDINONE DERIVATIVES OXA1L, MRPL21, ALPL MAOB 553/4885MAOA 330/4885PTGS1 3630/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.